Evolution of GPI-Aspartyl Proteinases (Yapsines) of Candida spp

Degradation of human kininogens with the release of kinin peptides by extracellular proteinases of Candida spp.

The secretion of proteolytic enzymes by pathogenic microorganisms is one of the most successful strategies used by pathogens to colonize and infect the host organism. The extracellular microbial proteinases can seriously deregulate the homeostatic proteolytic cascades of the host, including the kinin-forming system, repeatedly reported to be activated during bacterial infection. The current stu...

Proteinases in Virulence and Pathogenesis Secreted Aspartyl Candida albicans

Three distinct secreted aspartyl proteinases in Candida albicans.

The secreted aspartyl proteinases of Candida albicans (products of the SAP genes) are thought to contribute to virulence through their effects on Candida adherence, invasion, and pathogenicity. From a single strain of C. albicans (WO-1) which expresses a phenotypic switching system, three secreted aspartyl proteinases have been identified as determined by molecular weight and N-terminal sequenc...

Role of Aspartic Proteinases in Candida Albicans Virulence. Part I. Substrate Specificity of Aspartic Proteinases and Candida Albicans Pathogenesis Rola Proteazy Aspartylowej W Wirulencji Candida Albicans Część I. Specyficzność Substratowa Proteazy Aspartylowej a Patogeneza Zakażeń Candida Albicans

Candida albicans resides mainly as a harmless commensal in the gastrointestinal tract, vagina and some cutaneous areas of humans. However, in individuals who are immunocompromised or debilitated in some other way, C. albicans is responsible for superficialy-localized or systemic infections. Candida albicans produces a large family of secreted aspartyl proteinases (Saps) which are key virulence ...

Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species.

Aspartyl proteases are a class of enzymes that include the yeast aspartyl proteases and secreted aspartyl protease (Sap) superfamilies. Several Sap superfamily members have been demonstrated or suggested as virulence factors in opportunistic pathogens of the genus Candida. Candida albicans, Candida tropicalis, Candida dubliniensis and Candida parapsilosis harbour 10, four, eight and three SAP g...